Lamins
نویسندگان
چکیده
منابع مشابه
Lamins
Xie and Burke discuss the roles of lamins in nuclear morphology and the pathological consequences of defects in these nuclear envelope proteins.
متن کاملLamins for differentiation
O n page 83, Dorner et al. report that overexpression of a lamina-associated pro tein slows cell proliferation and promotes differentiation in vitro. The fi ndings suggest that laminopathy symptoms may not be due to structural weakness in the tissue, but rather to a failure of stem cells to properly regenerate damaged or aging tissues. A-type lamins are found at the nuclear periphery and in the...
متن کاملLamins at a glance.
Lamins, the major components of the nuclear lamina, have gained rapidly increasing interest over the past decade as lamin mutations were found to cause numerous devastating diseases. These laminopathies include Emery–Dreifuss muscular dystrophy (EDMD), dilated cardiomyopathy type 1A, limb-girdle muscular dystrophy type 1B, familial partial lipodystrophy (FPLD), Charcot–Marie–Tooth disease type ...
متن کاملLamins in disease
The nuclear envelope (NE) creates a compartment within the interphase cell in which DNA replication, transcription and RNA processing can be regulated independently of translation. Components of the NE include the inner nuclear membrane (INM) and outer nuclear membrane (ONM), nuclear pore complexes (NPCs) and the nuclear lamina. The lamina is a fibrous nucleoskeletal structure associated with t...
متن کاملNuclear lamins in cancer.
Dysmorphic nuclei are commonly seen in cancers and provide strong motivation for studying the main structural proteins of nuclei, the lamins, in cancer. Past studies have also demonstrated the significance of microenvironment mechanics to cancer progression, which is extremely interesting because the lamina was recently shown to be mechanosensitive. Here, we review current knowledge relating ca...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2016
ISSN: 0960-9822
DOI: 10.1016/j.cub.2016.01.055